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Acetaminophen and naproxen have been available over the counter for decades, and patients and clinicians already use them together

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Excessive APAP metabolism depletes glutathione and increases N-acetyl-p-benzoquinoneimide (NAPQI) levels, leading to oxidative stress, DNA damage, and cell necrosis in the liver, which in turn leads to liver damage

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Targeting glucose metabolism Since glucose metabolism is the most researched field in cancer metabolism, anticancer drugs blocking glucose metabolism-related enzymes and regulators are increasingly promising [299]