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Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis
Brand positioning of these products as supporting natural GLP-1 production represents their marketing claims and has not been evaluated by the FDA
doi:10.1016/S0140-6736(25)01201-2
3 Indirect modulation: the suppression of sulfonylurea-mediated activation of Epac2A on diverse ion channels Adenosine 3,5,-monophosphate (cAMP), an important second messenger, has been well established as a key regulator for the insulin release during the glucose stimuli, which is mediated via PKA-dependent manner and PKA-independent manner (as known as Epac2A way) (Shibasaki et al., 2014)
Sensitivity Analysis , chap
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