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The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

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This selectivity profile is what distinguishes FOXO4-DRI from broader cytotoxic agents and makes it the primary peptide tool for selective senescent cell elimination in the cellular senescence research field