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In the 28-week, phase three randomized control trial (RCT) DURATION-8, dual therapy with an SGLT2 inhibitor (dapagliflozin) and a GLP-1RA (once-weekly exenatide) was shown to reduce HbA1c by 0.4% more than either agent alone, in patients with a starting HbA1c of between 8-12% 50 , illustrating that the glycemic response to dual therapy is less than additive 50

MDL number: MFCD00063106

Nutritional support: Plans focus on managing calories and maintaining steady weight loss

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Research also indicates that people who take these medications are at increased risk of gastrointestinal events, such as pancreatitis, bowel obstruction, or gastroparesis