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In the CVOT, SUSTAIN 6, subcutaneous semaglutide was associated with a higher risk of diabetic retinopathy complications than placebo after 2.1 years ( 1c reduction in patients with pre-existing diabetic retinopathy ( Subcutaneous semaglutide significantly reduced the rate of MACE vs

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Those who got the drug lost close to 15 percent of their body weight, on average, compared with 2.4 percent among those receiving the placebo

Also, the weight loss from GLP-1 and GIP supplements is often kept off