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Reduced frequency maintains tissue support while minimizing ongoing costs and administration burden

Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges

In healthy individuals, skeletal muscle MBF increases in response to insulin or following a meal which facilitates glucose disposal [5]

Tsui SM, Ahmed R, Amjad N et al (2020) Single red blood cell analysis reveals elevated hemoglobin in poikilocytes