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This IR cascade initiates a characteristic sequence of metabolic and oxidative perturbations within mitochondria: succinate accumulation during ischemia, reverse electron transport-driven ROS generation upon reperfusion, calcium overload, opening of the mPTP, and ultimately, release of mtDAMPs
Li Y, Chen Y
We reiterate that in the case of NS, chronic biological disturbances cause fluctuations in antioxidant levels, a phenomenon also observed in the case of infectious processes related to the activation of systemic inflammatory pathways
Landes Company, 119-161
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