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This indole compound has the ability to promote the expression of cell-junction-associated molecules, such as occludin and claudins, by activating the pregnane X receptor, thereby enhancing the integrity of intestinal epithelial cells (101) ( Figure 3 )

Thyroid function should be monitored more frequently in autoimmune thyroid patients taking tirzepatide, and any new thyroid nodules or changes in thyroid function should be investigated promptly

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The reason for this sex difference isnt clear