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"Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization." Nature Medicine

In a Phase 2b obesity trial , AOD-9604 did not produce statistically significant weight loss versus placebo , and pharmaceutical development was discontinued around 2007 [3] [4]

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Much of the foundational research also comes from a single research group, which limits the breadth of independent validation

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