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Atkuri KR et al
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The isolated fraction induced delta-wave (slow-wave) sleep when injected into recipient animals giving the peptide its name and initiated one of the most distinctive research trajectories in neuropeptide biology: a compound with a clearly demonstrated biological name-property, an exceptionally wide pharmacological activity profile, and nearly five decades later a receptor that remains formally uncharacterised
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Importantly, semaglutide has received regulatory approval from the US FDA, with **Ozempic** being approved in 2017, **Rybelsus** in 2019, and **Wegovy** in 2021
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