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Andrew Huberman: I find that fascinating
Conclusion Weight alters your fertility odds
In this 52-week trial of 1,698 people with type 2 diabetes whose blood sugar wasn't adequately controlled on Metformin, orforglipron outperformed oral semaglutide on every primary and secondary endpoint, including A1C reduction and weight loss, with improvements visible as early as four weeks
Given the metabolic benefits of GLP-1RAs, caution is advised in patients with a history of depression or psychiatric vulnerability and a heightened vigilance for these events is warranted
It notes that research settings can track drug levels using mass spectrometry or isotope labelling, but says those methods are not available in typical outpatient care
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