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The rationale is there, but the real-world results just dont compare to prescription GLP-1s

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Managing Expectations & Practical Guidance for Patients As orforglipron moves toward approval and commercial availability, patients, providers, and the broader public will need realistic expectations about what this drug can and cannot do

Another meta-analysis of randomized controlled trials found that endothelial function in normal-weight and overweight but not obese patients with type 2 diabetes was significantly improved by supplementation with vitamin E and/or vitamin C (90)