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E1 is a thiamin pyrophosphate (TPP)-dependent -ketoacid dehydrogenase, R -lipoic acid functions as a prosthetic group essential for E2 transacetylase activity, and E3 is a flavin adenine dinucleotide (FAD)-dependent dihydrolipoamide dehydrogenase ( Figure 4 )

Tarhini, M., Greige-Gerges, H

*Based on Pharmacy Times 2024 survey (upset stomach remedies category) *Use as directed for relief of upset stomach, heartburn, indigestion, nausea due to overindulgence (in food and drink) and diarrhea.

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Biomed Res Int 2017:4614183 Mahmoud AM, Abd El-Twab SM (2017) Caffeic acid phenethyl ester protects the brain against hexavalent chromium toxicity by enhancing endogenous antioxidants and modulating the JAK/STAT signaling pathway