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When patients lose significant weight with GLP-1 receptor agonists, the body's centre of gravity shifts, and the biomechanical load on the spine changes

Natural Ingredients No

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Behavioral intervention consisted of counseling by a dietitian or similarly qualified healthcare professional every 4 weeks via in-person visits or telephone on adherence to a reduced-calorie diet (500 kcal deficit a day relative to the energy expenditure estimated at randomization) and increased physical activity (150 minutes a week encouraged, for example, walking), both recorded daily (via a diary, app or other tools, which were reviewed during counseling sessions)

In Phase 2, monotherapy at 4.5 mg/week reached 10.8% at 26 weeks