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Glutathione metabolism in canine hereditary stomatocytosis with mild erythrocyte glutathione deficiency

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Key findings: (1) Aged Fischer 344 rats showed restoration of spatial memory (Morris water maze) after subcutaneous Dihexa treatment at picomolar doses

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Treatment of p47phox knockout animals with DOCA-salt markedly reduced levels of oxidative stress and abolished superoxide reducing effects of NOS inhibition compatible with a prevention of eNOS uncoupling