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Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha
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Moreover, a post hoc exploratory analysis of the large CREDENCE trial, including 4401 patients with T2DM and chronic kidney disease reported no significant difference in neuropathy events between canagliflozin and placebo groups, indicating no clear effect of canagliflozin on sensorimotor polyneuropathy or other neuropathic outcomes over a median follow-up of 2.5 years
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