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Several trials have reported that 35% to 45% of GLP-1 weight loss is not fat, but lean mass including muscle and bone

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The excess symptom rate above placebo is roughly 15% in controlled trials

The post separates lower-risk options, acetaminophen, antihistamines, and cough suppressants such as dextromethorphan, from those it says require case-by-case assessment: NSAIDs, decongestants, and expectorants