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February 28, 2025

Conclusions Mechanistic and preliminary clinical evidence have consistently pointed toward beneficial effects of GLP-1 analogues and GLP-1R agonists on cardiovascular diseases in T2D patients

Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity - Frontiers in Endocrinology Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity - JAMA Internal Medicine Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes - New England Journal of Medicine Tirzepatide for Diabetes Improves Glycemic Control After Switch From GLP-1RA - Endocrinology Advisor Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension - Diabetes, Obesity and Metabolism

This targeted approach to weight loss makes GLP-1 therapy ideal for patients seeking sustainable, transformative results beyond what traditional methods can achieve

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