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M1-dominant macrophages overproduce TNF- and IL-6, directly blocking insulin receptor signalling in metabolically active tissues [4]
Because so many pathways are implicated at once, most research protocols isolate a small panel of markers, such as collagen I/III ratios or a single antioxidant enzyme, rather than tracking every reported change simultaneously
The expression of FOXO4 in the cytoplasm of keloid fibroblasts was significantly lower than that in normal skin fibroblasts ( p = 0.03
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