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doi: 10.3389/fphar.2025.1526270 Received 11 November 2024 Accepted 28 January 2025 Published 17 February 2025 Volume 16 - 2025 Edited by Alessandra Linardi, Santa Casa de So Paulo School of Medical Sciences, Brazil Reviewed by David Pubill, University of Barcelona, Spain Ariadiny Lima Caetano, Santa Casa de So Paulo School of Medical, Brazil Updates Copyright 2025 Wang, Hao, Ma, Feng, Yang, An, Su and Feng
Zhang AQ, Mitchell SC, Smith RL
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Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 ( via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)
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