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Excessive APAP metabolism depletes glutathione and increases N-acetyl-p-benzoquinoneimide (NAPQI) levels, leading to oxidative stress, DNA damage, and cell necrosis in the liver, which in turn leads to liver damage

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A brief diet intervention can reduce symptoms of depression in young adultsA randomised controlled trial

*Gentle shampooing*: Use a gentle, sulfate-free shampoo to minimize hair breakage

Mechanism of action: melanocortin cAMP/PKA/MITF cascade Presynaptic activation of cutaneous MC1R and central MC3R/MC4R/MC5R PRIMARY PATHWAY MELANOGENESIS MC1R on melanocytes High-affinity binding to the MC1R receptor on epidermal melanocytes