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That is an issue because a dehydrated athlete will have more concentrated urine relative to a well-hydrated athlete, and so the concentration of any substances (prohibited or not) appearing in their urine will be higher, thus increasing the probability of an anti-doping rule violation being pursued against them simply because of their hydration status
However, under oxidative stress conditions, Nrf2 dissociates from Keap1 and translocates to the nucleus, where it activates various antioxidant genes, including HO-1, protecting cells from oxidative damage
It also helps regulate homocysteine levels, promoting cardiovascular health
Interestingly, they could reach an ability to detect this increase in lactate with as little as 5% of tumor content in the biopsy, making it a promising tool for PC detection [180]
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