Katagiri, M., Satoh, A., Tsuji, S., & Shirasawa, T
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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)
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This observation suggests that radial axonal sorting, ensheathment, and potentially metabolic support are ancient glial functions that predate the evolutionary emergence of myelin in jawed vertebrates (Silva et al., 2022