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2 Trulicity was first approved in September 2014 as a once-weekly injectable prescription medicine to improve blood sugar (glucose) in adults with type 2 diabetes, based in part on results from five Phase 3 studies of Trulicity used alone or in combination with other diabetes medications, including metformin, pioglitazone, glimepiride and insulin lispro

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Unlike orlistat, which blocks fat absorption, or phentermine, which is a stimulant-based appetite suppressant, GLP-1 receptor agonists address hunger and satiety at the hormonal level, targeting a fundamental aspect of overeating

The catch is that lower dose is not automatically same result at less risk. A dose that is too low for your biology may simply underperform while still carrying side effects

Funding This research was funded by Deanship of Research and Graduate Studies at King Khalid University through Large Research Project under grant number RGP2/580/45