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In this 52-week trial of 1,698 people with type 2 diabetes whose blood sugar wasn't adequately controlled on Metformin, orforglipron outperformed oral semaglutide on every primary and secondary endpoint, including A1C reduction and weight loss, with improvements visible as early as four weeks

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Since one of our top picks in this guide is a multivitamin, its worth noting that were not suggesting people in the above groups avoid all supplements entirely