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this risk is known to increase with age, and is more common in women (1.5 times compared with men) ( In an AD mouse model, GLP-1RAs were demonstrated to reduce the levels of AD pathological markers, including oligomeric antibodies and antibody plaque load, reduce the activation of microglia, and improve memory behavior ( 2+ and hypoxia

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While the exact mechanisms remain to be fully elucidated, proposed pathways include modulation of dopamine release, suppression of neuroinflammation, and attenuation of stress-related neural circuits (27)

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