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Nearly 85% of patients without T2DM stopped taking GLP-1s within two years

Important safety considerations include a boxed warning for medullary thyroid carcinoma risk, monitoring for pancreatitis (severe abdominal pain), gallbladder disease, and potential hypoglycemia when used with insulin or sulfonylureas

For larger time zone shifts, gradual adjustment over two to three weeks works well

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Studies indicate that individuals with pancreatic risk factors or a history of pancreatic disease may need to exercise additional caution when using GLP-1 and GIP receptor agonists