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This leads to the accumulation of extracellular matrix (ECM) and, ultimately, the development of tubulointerstitial fibrosis (76)
After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)
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The physiological benefits of GLP-1 medicationssuch as improved insulin sensitivity and reduced food noiseaccrue over weeks and months