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Toxicity is rare and mainly affects people with kidney problems
In Gpx4 knockout cells, GCH1 overexpression can significantly protect cells from ferroptosis, and GPX4 and glutathione levels are not affected by GCH1 overexpression
This differs from the majority of heparin-binding proteins, which bind through basic amino acid sequences containing primarily lysine and arginine (Hileman et al., 1998), but is common for histidine-proline-rich glycoprotein (HPRG) (Liu et al., 2018)
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