tirzepatide who should not take Avoid Tirzepatide? Safety Guidelines in Diabetes Treatment How to Stop Taking Tirzepatide:

These APIs are typically administered via subcutaneous injection, either once or twice daily, or in some cases, as weekly formulations

Your doctor may discuss these concerns with you beforehand

ALS is mostly diagnosed based on clinical signs, using the revised El Escorial criteria, which require signs of both upper motor neuron (e.g., spasticity, brisk reflexes) and lower motor neuron damage (e.g., muscle wasting, twitching) in multiple body regions (Brotman et al., 2025)

Second, the medication slows gastric emptying and reduces appetite, sometimes leading to lower overall nutrition intake if patients don't eat intentionally balanced meals

This led to it being used off-label as a weight loss drug