This approach is particularly effective for people whose constipation has not responded adequately to fiber taken with meals
The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals
Moreover, the SELECT study showed that semaglutide significantly reduced the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke (hazard ratio 0.80) ( 6 Practical issues when prescribing GLP-1RA in T1D GLP-1RA are not currently approved for treatment of T1D, but they may still be covered by insurance if prescribed to treat obesity in these patients (although insurance coverage for obesity remains limited)
Its impossible to know whether a peptide will be safe for you without consulting a physician who can consider your medical history, Husain adds
We believe plan sponsors should start preparing now for increased demand and develop a program approach that balances providing access with maintaining benefit affordability.