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Furthermore, in a 12-week RCT in which patients were either assigned to liraglutide (1.8 mg/day), sitagliptin (100 mg/day) or placebo, no difference in glycemic control or bodyweight reductions were found, and both treatments failed to reduce liver hepatic fat content compared to placebo (69)
Error bars reflect the SEM unless otherwise noted, and the data are averaged across more than three different experiments
Dementia 1991;2(6):333-337
Rybelsus (semaglutide) is the first FDA-approved oral GLP-1 agonist for patients with type 2 diabetes to improve blood sugar levels when combined with exercise and lifestyle changes
Some early data hints at modest changes, but this is not firmly settled, and B12 depletion is far more strongly linked to other medications (such as metformin) than to semaglutide
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