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Subsequent trials, including AWARD-10 and SUSTAIN-9, further confirmed the efficacy of intensification strategies, demonstrating meaningful improvements in glycemic control and body weight when one class is added to the other [31, 32]

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GLP-1 can directly bind to the receptors on the surface of -cells in the pancreas, inhibiting the secretion of glucagon from these cells.234,235 Glucagon is a hormone secreted by pancreatic -cells that stimulates the liver to release glucose

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