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This epigenetic regulation involves copper-dependent activation of cellular pathways including enhanced DNA repair, increased antioxidant enzyme production, and stimulation of regenerative processes while simultaneously suppressing inflammatory and destructive gene programs

Its primary role is to upregulate proteins like actin, which is critical for cell migration, proliferation, and differentiation

The plasmids were then extracted by a NucleoSpin plasmid kit (Macherey-Nagel, 740588) and sent for sequencing (Eurofins genomics)

doi: 10.1016/j.nut.2018.06.019 58 ZimmerTSDavidBBroekaartDWMSchidlowskiMRuffoloGKorotkovAet al