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The observed inconsistencies across studies likely result from variations in sample sizes, ethnic backgrounds, and age groups

Women who were pregnant, lactating, or had not adhered to adequate contraception from at least 30 days prior to the study entry and did not plan to for 1 month after the final supplementation were also excluded

We hypothesize that conformer 1 is required for G protein activation, and that adoption of this receptor conformation is favored under conditions used to form a stable complex that can be imaged (inclusion of dominant negative G protein and nanobody 35, apyrase treatment)

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