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Lee E, et al

GLP-1 Medications May Activate Visceral Fat Valerie Sutherland, MD Aug 9, 2025 2 min read If youve heard about GLP-1 medications like Wegovy, Zepbound, or Saxenda , you know they help people lose weight by reducing appetite and slowing digestion

[8] [9] This sympathetic activation may be mediated through central nervous system pathways, as GLP-1 receptors are present in the hypothalamus and brainstem regions that regulate cardiovascular function

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And although these side effects can occur no matter how well youre taking care of yourself, they may be worse if youre eating large meals, spicy or fatty foods, or drinking large amounts of liquids while eating