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We generated fully human antibodies to specifically block GDF8 (trevogrumab) and ActA (garetosmab), and showed that combining these blocking antibodies results in much greater increases in muscle than either of the antibodies individually, with dual blockade matching the muscle growth induced by broader ActRIIA/B pathway blockade in both mice and non-human primates (NHPs) 28,31
J Nutr Biochem 25:329336
& Cordelieres, F
Statistical source data for the supplementary figures are available in Supplementary Data 3
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