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J Neuropathol Exp Neurol 57 (4), 338342

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275,276 The phagocytic NADPH oxidase complex can also be activated by Rubicon to induce a ROS burst, inflammatory cytokine production and potent antimicrobial activities

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Therefore, the ratio between reduced and oxidized forms of GSH is an important indicator of the redox environment and, at the same time, contributes to the accomplishment of the molecular mechanisms underlying cell proliferation, differentiation or death in the form of apoptosis (Dickinson and Forman, 2002)