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Neelakantan and colleagues (Biochem Pharmacol, 2018) reported that 1-methylquinolinium and 1-methylnicotinamide showed no measurable passive diffusion in their assays, whereas 5-amino-1MQ crossed by both passive and active routes with no detectable efflux in Caco-2 cells, and lowered intracellular 1-methylnicotinamide in differentiated 3T3-L1 adipocytes with an EC near 2.3 M
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Every 0.25mL you draw delivers exactly 5mg
Composition 5-amino-1MQ: 5 mg Appearance: lyophilized powder in a sealed research vial Research Focus (non-clinical) Investigation of NNMT inhibition and its downstream metabolic effects Studies on NAD+ metabolism and energy homeostasis in preclinical models Development of analytical methods for small-molecule quantitation Stability and solubility assessment of 5-amino-1MQ under laboratory storage conditions Documentation Lot-specific COA available Batch and lot traceability Important Notice For research use only Not for human consumption Not intended to diagnose, treat, cure, or prevent any disease Quality & Manufacturing Lot-specific COA Lyophilized for transit stability
How It Is Studied In laboratory research, AOD-9604 is typically administered to cell cultures or animal models and assessed using lipolysis assays, which measure free fatty acid release from adipocytes
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