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doi: 10.1210/jc.2011-3350 28 BaroniMGGiorginoFPezzinoVScaroniCAvogaroA
In the subgroup analysis by outcome measures, there were no statistically significant groups (Fig
The MITF (microphthalmia-associated transcription factor) pathway is simultaneously upregulated downstream of PKA/CREB activation, serving as the master transcriptional regulator that coordinates the entire melanogenic enzyme cascade, and this cAMP-PKA-CREB-MITF axis represents the canonical signaling pathway measured in Melanotan II potency assays
Its ability to cross the blood-brain barrier means it plays an important role in removing toxins, such as mercury, from the brain and other cells
