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Mosialou I, Shikhel S, Liu J-M, Maurizi A, Luo N, He Z, et al
We critically evaluate the effectiveness of the approach and give recommendations for evaluation of brain delivery efficacy by transporter-utilizing delivery systems based on CNS pharmacokinetic principles
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demonstrated that both Fer-1 and SRS11-92, specific ferroptosis inhibitors, significantly enhance survival in striatal neurons expressing mutant huntingtin in a dose-dependent manner, providing initial evidence that targeting ferroptosis may offer therapeutic benefits in HD (401)
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