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3h, i of mice treated with 100 nmol kg 1 MK-801 ( n = 8 mice and n = 4 cages), 100 nmol kg 1 GLP-1 ( n = 8 mice and n = 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice and n = 4 cages) or vehicle (isotonic saline, n = 8 mice and n = 4 cages) for 5 days
Adherence to antihyperglycemic medications and glucagon-like peptide 1-receptor agonists in type 2 diabetes: clinical consequences and strategies for improvement
Because these medications slow stomach emptying and reduce appetite, a portion that once felt normal may now cause nausea, reflux, bloating, or hours of uncomfortable fullness
This psychological lag is normal and gradually resolves as the new body becomes the familiar one
At the time, the notion that one molecule could have two separate effects was provocative, as was the thought of having a novel injectable medicine for these conditions
