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The binding sites of hyperoside, narcissoside, cyaniding 3-O-glucoside, and isoliquiritigenin were found within the active site cavity of DPP-4, while myricetin's binding site was found in a minor cavity close to the active pockets (115)

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Probiotics, in particular, offer multifaceted benefits by restoring microbial balance, producing SCFAs that enhance intestinal barrier integrity (181), and modulating immune responses via Toll-like receptor (TLR) signaling (182)

As a general procedure, the investigators directly performing the experimental procedures were not blinded to the group allocation, but data analyses by senior authors were largely conducted independently to avoid potential bias