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Specifically, tendons are highly collagenous, so anyone who's straining their tendons on a regular basis (with intense exercise or heavy lifting) should make collagen-synthesis support a priority
The remaining fraction undergoes sulfation to the active metabolite
Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin
Gut hormones-based pharmacology: novel formulations and future possibilities for metabolic disease therapy
Hurtado, Maria D., et al
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