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Quercetin and other polyphenols inhibit NLRP3 inflammasome assembly, thereby reducing caspase-1 activation and limiting the release of (IL-1, IL-18), this results in a significant reduction in neuroinflammatory cytotoxicity (Xue et al., 2017)
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Poor sleep compounds the issue just four nights of sleeping five hours can reduce insulin sensitivity by about 20%
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